Is social deprivation associated with the peritoneal dialysis outcomes? A cohort study with REIN registry data.

BACKGROUND: Social deprivation is associated with lower peritoneal dialysis (PD) uptake. This study was carried out to evaluate the role of social deprivation on the outcome of PD. METHODS: This was a retrospective study of data extracted from the Renal Epidemiology and Information Network registry for patients older than 18 years who started PD in metropolitan France between 1 January 2017 and 30 June 2018. The end of the observation period was 31 December 2020. The exposure was the European Deprivation Index calculated using the patient's address. The events of interest were death, transfer to haemodialysis (HD), transplantation and the composite event of death or transfer to HD. A Cox model and Fine and Gray model were used for the analysis. RESULTS: A total of 1581 patients were included, of whom 418 (26.5%) belonged to Quintile 5 of the European Deprivation Index (the most deprived patients). In the Cox model, the most deprived subjects did not have a greater risk of death (cause-specific hazard ratio (cs-HR): 0.76 [95% confidence interval (CI): 0.53-1.10], transfer to HD (cs-HR 1.37 [95% CI: 0.95-1.98]) or the composite event of death or transfer to HD (cs-HR: 1.08 [95% CI: 0.84-1.38]) or a lower risk of kidney transplantation (cs-HR: 0.73 [95% CI: 0.48-1.10]). In the competing risk analysis, the most deprived subjects had a higher risk of transfer to HD (subdistribution hazard ratio (sd-HR): 1.54 [95% CI: 1.08-2.19]) and lower access to kidney transplantation (sd-HR: 0.68 [0.46-0.99]). CONCLUSION: In PD patients, social deprivation was not associated with death or the composite event of death or transfer to HD. Socially deprived individuals had a greater risk of transfer to HD and lower access to kidney transplantation in the competing risk analysis.

Sex-related differences in pre-dialysis trajectories and dialysis initiation: A French nationwide retrospective study.

BACKGROUND: In the last two decades, sex and gender differences have been documented in chronic kidney disease (CKD) management, including access to renal replacement therapy and its outcomes. The objectives of this study were to 1) compare the pre-dialysis healthcare utilization in men and women, and 2) examine the sex-specific factors associated with emergency dialysis start. METHODS: Adult patients with CKD who started dialysis in France in 2015 were extracted from the Renal Epidemiology and Information Network registry. Patients were matched to the French National Health Data System database to extract healthcare utilization data for the 2 years before dialysis start. Frequencies and monthly rates of consultations and hospitalizations were compared between men and women. Logistic regression analyses were performed separately in the two groups. RESULTS: Among the 8856 patients included, 3161 (35.7%) were women. Median age (71 years) and estimated glomerular filtration rate (8.1 and 7.7 ml/min for men and women) were similar between groups at dialysis start. Monthly consultations rates with a general practitioner and nephrology-related care were similar between women and men. Some sex-specific differences were found: higher frequencies of consultations with a psychiatrist in women and more frequent hospitalizations for circulatory system diseases in men. Emergency dialysis start rate was 30% in both groups. Emergency dialysis start was associated with acute nephropathy, compared with slowly progressive nephropathy, in women but not in men (OR = 1.48, p<0.01 vs 1.15, p = 0.18). CONCLUSIONS: This study found similar quantitative pre-dialysis healthcare utilization in men and women. To better understand sex/gender differences in CKD care trajectories, future research should focus on patients with CKD who are unknown to nephrology services, on patients receiving conservative care and on the sex/gender-specific mechanisms underlying care decision-making.

Sex disparities in the utilization of nurse-assisted peritoneal dialysis: a mediation analysis using data from the REIN registry.

Background: This study was carried out to evaluate the association between patient sex and the proportion of nurse-assisted peritoneal dialysis (PD) at dialysis initiation and to explore whether sex disparities in nurse-assisted PD utilization was explained by predialysis care and/or by social deprivation using mediation analysis. Methods: This was a retrospective study using data from the Renal Epidemiology and Information Network (REIN) registry linked to the French National Healthcare Database (SNDS) of incident patients between 1 January 2017 and 30 June 2018. A regression logistic was used for statistical analysis. A mediation analysis explored the direct effect of sex on nurse-assisted PD proportion and the indirect effect through the European Deprivation Index (EDI), and the number of general practitioner (GP) and nephrologist visits before dialysis initiation. Results: Among 1706 patients on PD, there were 637 women (37.3%) and 1069 men (62.7%). Nurse-assisted PD proportion was 332/610 (54.4%) for women vs 464/1036 (44.8%) for men. In the multivariable analysis women were more likely to be treated by nurse-assisted PD {odds ratio (OR) 1.92 [95% confidence interval (CI) 1.46-2.52]}. Nurse-assisted PD was associated with the median number of GP visits [OR 1.44 (95% CI 1.11-1.86)] and with the median number of nephrologist visits [OR 0.59 (95% CI 0.46-0.76)]. The mediation analysis showed a direct effect of sex on nurse-assisted PD [OR 1.90 (95% CI 1.80-2.01)] and an indirect effect through the median number of GP visits [OR 1.05 (95% CI 1.04-1.06], the median number of nephrologist visits [OR 1.02 (95% CI 1.02-1.03)] and quintile 5 of the EDI [OR 1.03 (95% CI 1.02-1.03)]. Conclusion: Women were more frequently treated by nurse-assisted PD than men. Differences between women and men in predialysis care and social deprivation could explain the greater utilization of nurse-assisted PD among women.

The impact of cat-related peritonitis on peritoneal dialysis outcomes: Results from the RDPLF.

BACKGROUND: Cat ownership is common in peritoneal dialysis (PD) patients, even with recent guidelines recommending avoiding domestic animals during PD exchanges to limit the risk of peritonitis due to pet contamination. We analysed the outcomes of patients who experienced cat-related peritonitis compared with those who experienced peritonitis due to other causes. METHODS: This retrospective study based on the Registre de Dialyse Peritoneale de Langue Française data analysed the outcomes of 52 patients experiencing cat-related peritonitis from the beginning of the database (1986) until 21 June 2022 compared with those of 208 matched patients experiencing peritonitis due to other causes. A Cox regression model examined the association between cat-related peritonitis and the composite end point of death in PD or transfer to haemodialysis (HD), death in PD and transfer to HD. RESULTS: Among patients with an episode of cat-related peritonitis, 11 (21.1%) died, 19 (36.5%) were transferred to HD and 11 (21.1%) were transplanted. In the group with other causes of peritonitis, these numbers were 67 (32%), 81 (39%) and 26 (12.5%), respectively. In multivariate survival analysis, age (hazard ratio (HR): 1.39; 95% confidence interval (CI): 1.13-1.70) and use of assisted PD (HR: 4.07; 95% CI: 2.11-7.86) were associated with the risk of death. Having experienced cat-related peritonitis was not significantly associated with any of the three outcomes (death, transfer to HD or PD cessation). CONCLUSIONS: Patients on PD should be aware that cats may cause a peritoneal infection, which results in similar consequences to those of other causes of peritonitis. However, pets at home should not be considered a contraindication to PD.

Incidence of End Stage Kidney Disease and context of dialysis initiation / Incidence de la maladie rénale chronique stade 5 traitée par suppléance et contexte d'initiation de la dialyse

On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue of ESKD incidence, the following key messages were retained. Thanks to several studies conducted using data from the REIN registry, the spatial variations of incidence of stage 5 chronic kidney disease in the replacement stage could be explained, in part, by the health condition of the general population as well as by the socio-economic context and differences in practices. Just like what is observed in other countries, the incidence is stabilising, or even decreasing, especially among people who do not have diabetes. Thanks to the registry having provided an indicator on the initiation of the dialysis, a decrease in the rate of initiation of emergency dialysis (i.e., initiated less than 24 hours after a nephrology evaluation considering a vital risk for the patient) has been observed, resulting from an effort to understand and better anticipate the starting of the replacement.

À l'occasion des 20 ans du REIN (Réseau Epidémiologie et Information en Néphrologie), un travail de synthèse sur les apports du registre a été mené. Sur la question de l'incidence de la maladie rénale chronique stade 5, les messages clés suivants ont été retenus. Grâce à plusieurs études menées à partir des données du registre REIN, les variations spatiales d'incidence de la maladie rénale chronique stade 5 au stade de la suppléance ont pu être expliquées, en partie, par l'état de santé de la population générale mais aussi par le contexte socioéconomique et des différences de pratiques. À l'image de ce qui est observé dans d'autres pays, l'incidence est en voie de stabilisation, voire à la baisse, en particulier chez les personnes non diabétiques. Grâce à la mise à disposition par le registre d'un indicateur sur l'initiation de la dialyse, on observe une diminution du taux d'initiation de la dialyse en urgence (c'est-à-dire initiée moins de 24 heures après une évaluation néphrologique considérant un risque vital pour le patient) résultant d'un effort pour comprendre et mieux anticiper le démarrage de la suppléance. L'initiation de la dialyse sur cathéter, autre indicateur de la prise en charge, n'a pour l'instant pas diminué mais avec la mise en place du forfait MRC en octobre 2019 et à distance de la pandémie, la préparation à l'épuration extrarénale devrait être mieux anticipée.

REIN: a tool at the service of the patients / REIN : un outil au service des patients

On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue of patients' perspectives, the following key messages were retained. As shown by the SONG (Standardised Outcomes in Nephrology) initiative, the criteria for judging the dialysis treatment that patients and care-givers prefer are not those that are traditionally found in published studies. For example, for haemodialysis, they are fatigue, ability to travel, time without dialysis, impact on family and ability to work. The concern to give the patients a voice has been at the heart of the REIN registry right from the outset. In addition, there are patient representatives in the REIN Scientific Council and the Steering Group. Although mainly focused on quantitative health data collected from professionals, REIN has also supported studies pertaining to data collected directly from patients. These studies enable addressing questions pertaining to the problems faced by patients in their care pathway and their life with the disease. The setting up of a tool for routine and electronic collection of the patients' point of view in the evaluation of their treatment and the support of patient-initiated research contribute to positioning the REIN as a partner tool at the service of patients, unique in France.

À l'occasion des 20 ans du REIN (Réseau Épidémiologie et Information en Néphrologie), un travail de synthèse sur les apports du registre a été mené. Sur le point de vue des patients avec une maladie rénale stade 5, les messages clés suivants ont été retenus. L'initiative SONG (Standardised Outcomes in Nephrology) l'a montré, les critères de jugement de la prise en charge en dialyse que les patients et aidants privilégient ne sont pas ceux que l'on retrouve traditionnellement dans les études publiées. Par exemple, en hémodialyse, il s'agit de : la fatigue, la capacité à voyager, le temps sans dialyse, l'impact sur la famille et la capacité à travailler. La préoccupation de donner la parole aux patients a d'emblée été au coeur du registre REIN. En outre, des représentants de patients siègent au conseil scientifique REIN et au sein du groupe de pilotage. Bien qu'essentiellement orienté sur des données de santé quantitatives recueillies auprès des professionnels, REIN a également soutenu les études portant sur des données recueillies directement auprès des patients. Ces études permettent d'aborder des questions proches des problématiques des patients sur leurs parcours de soins et leur vie avec la maladie. La mise en place d'un outil de recueil électronique et de routine du point de vue des patients dans l'évaluation de leur prise en charge et le soutien de recherches à l'initiative des patients participent à positionner le REIN comme outil partenaire au service des patients, unique en France.

REIN: a tool at the service of the paediatric patients / REIN : un outil au service des patients pédiatriques

On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue of paediatric CKD patients, the following key messages were retained. Paediatric stage 5 chronic kidney disease (CKD) has particularities that require to be analysed and taken into account because the mortality of these patients remains 30 times higher than that of children of the same age. The REIN registry enables illustrating the specificities of stage 5 CKD in the paediatric age-group in France and providing a set of indicators making it possible to describe the future of these patients as well as the choices made concerning the modalities of replacement therapy. As compared to other European countries, the incidence and prevalence of stage 5 CKD in France is in the middle range for children under 15 and 20 years old. Renal transplant is by far the leading treatment for stage 5 CKD in children and adolescents under 18 years of age in France, allowing to offer these patients the best possible life expectancy. Owing to the small volume of patients, only a nationwide registry can provide an unbiased view and enables analysing this population requiring a hyperspecialised treatment. The participation of French paediatric nephrologists in the REIN French registry also enables providing input to the European registry (ESPN/ERA www.espn-reg.org/index.jsp) and the international registry (IPNA https://ipna-registry.org) (Consulted on September 15th 2022) and thus the possibility of international studies, which are vital to be in line with an approach to improving practices.

À l'occasion des 20 ans du REIN (Réseau Epidémiologie et Information en Néphrologie), un travail de synthèse sur les apports du registre a été mené. Sur la question des patients pédiatriques, les messages clés suivants ont été retenus. La maladie rénale chronique (MRC) stade 5 pédiatrique a des particularités qui nécessitent d'être analysées et prises en compte car la mortalité de ces patients reste 30 fois supérieure à celle des enfants du même âge. Le registre REIN permet d'illustrer les spécificités de la MRC stade 5 à l'âge pédiatrique en France et de fournir un ensemble d'indicateurs permettant de décrire le devenir de ces patients ainsi que les choix faits concernant les modalités de traitement de suppléance. En comparaison à d'autres pays européens, l'incidence et la prévalence de la MRC stade 5 en France se situent dans les valeurs moyennes chez les enfants de moins de 15 et 20 ans. La transplantation rénale est de loin le premier traitement de la MRC stade 5 parmi les enfants et les adolescents de moins de 18 ans en France, permettant d'offrir à ces patients la meilleure espérance de vie possible. En raison du petit volume de patients, seul un registre à l'échelon national permet d'avoir une vision non biaisée et d'analyser cette population nécessitant une prise en charge hyperspécialisée. La participation des néphropédiatres français au registre français REIN permet aussi d'alimenter le registre européen (ESPN/ ERA www.espn-reg.org/index.jsp) et le registre international (IPNA https://ipna-registry.org) (Consulté le 15 septembre 2022) et ainsi la possibilité d'études internationales, indispensables pour s'inscrire dans une démarche d'amélioration des pratiques.

REIN: a tool at the service of the elderly patients / REIN : un outil au service des patients âgés

On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue of elderly CKD patients, the following key messages were retained. The population of elderly dialysis patients continues to grow. These patients have multiple comorbidities including pathologies specific to the elderly like undernutrition, walking and cognitive disorders. The data from the REIN registry has been the subject of numerous studies pertaining to this group showing heterogeneous prognosis and treatment, requiring to be better evaluated to target an individualised treatment. Decision support tools have been developed using the registry data to help nephrologists and patients in deciding whether to start replacement therapy and whether to refer elderly patients for assessment for a renal transplant. Finally, the risk-benefit evaluation of the different replacement therapies in this population should be monitored at the registry level and on a case-by-case basis in clinical practice.

À l'occasion des 20 ans du REIN (Réseau Epidémiologie et Information en Néphrologie), un travail de synthèse sur les apports du registre a été mené. Sur la question des patients âgées, les messages clés suivants ont été retenus. La population des patients âgés en dialyse ne cesse de croître. Ces patients ont de multiples comorbidités dont des pathologies spécifiques aux personnes âgées comme la dénutrition, les troubles de la marche et de la cognition. Les données du registre REIN ont fait l'objet de nombreuses études portant sur ce groupe montrant un pronostic et une prise en charge hétérogènes, nécessitant d'être mieux évalués pour cibler une prise en charge individualisée. Des outils d'aide à la décision ont été développés à l'aide des données du registre pour aider les néphrologues et les patients dans la décision de démarrer ou non un traitement de suppléance et d'orienter ou non les patients âgés vers un bilan d'évaluation en vue d'une transplantation rénale. Enfin, l'évaluation du bénéficerisque des différents traitements de suppléance dans cette population doit être poursuivie à l'échelle du registre et au cas par cas en pratique clinique.

REIN: a tool to support scientific research / REIN : un outil au service de la recherche

On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue its role in research, the following key messages were retained. The growing number of publications, dissertations, theses and teams involved shows that the REIN registry has attained its objective of being a shared research infrastructure, in the field of epidemiology as well as in public health, health economics or medical data processing. REIN is a valuable tool for the study of specific kidney diseases, particularly for epidemiological data pertaining to rare diseases that may lead to stage 5 of a chronic kidney disease. The linkage with the data from the National Healthcare Data System enables integrating and analysing the medical treatments received by patients, before the initiation of the replacement therapy and towards the end, as well as the details of the hospital stays.

À l'occasion des 20 ans du REIN (Réseau Épidémiologie et Information en Néphrologie), un travail de synthèse sur les apports du registre a été mené. Sur la question de REIN comme outil au service de la recherche, les messages clés suivants ont été retenus. Le nombre croissant de publications, mémoires, thèses et d'équipes impliqués dans la valorisation des données démontre que le registre REIN a atteint son objectif d'être une infrastructure de recherche partagée, aussi bien dans le champ de l'épidémiologie que de la santé publique, que de l'économie de la santé ou l'informatique médicale. REIN est un outil précieux pour l'étude de pathologies rénales spécifiques, en particulier pour les données épidémiologiques de maladies rares pouvant conduire au stade 5 d'une maladie rénale chronique. Le couplage avec les données du Système national des données de santé (SNDS) permet d'intégrer et d'analyser les traitements médicaux reçus par les patients, en amont de l'initiation du traitement de suppléance et au décours, ainsi que le détail des séjours hospitaliers.

REIN: a tool at the service of health authorities / REIN : un outil au service des administrations sanitaires

On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue of its link with health authorities, the following key messages were retained. One of the purposes of REIN is to contribute to a better understanding about patient management and its evolution, and thus to be called upon to develop health strategies aimed at improving the prevention and treatment of chronic renal failure. Indeed, the planning of the supply and the evaluation of the treatment are important issues for the public health decision-makers who must have the relevant indicators and tools to help them in their decision-making and follow-up processes. REIN is clearly identified as a source of information by institutional partners, as is shown by the various requests made by the Regional health agencies (ARS), the French National Authority for Health (HAS) and the General Directorate for Healthcare Services (DGOS), as well as other health authorities. It allows estimating the needs of the population within the framework of decree nos. 2002-1197 and 2002-1198 of September 2002 relating to the treatment of chronic renal failure by renal dialysis. The recent possibility of probabilistic matching of REIN data with the data from the National Healthcare Data System (SNDS) for a pseudonymised individual allows for more detailed studies on the different care pathways, as well as evaluating the impact of the different actions or experiments that are set up, with the help of detailed clinical information from the REIN and, among other things, the expenses reimbursed by the Health Insurance.

À l'occasion des 20 ans du REIN (Réseau Epidémiologie et Information en Néphrologie), un travail de synthèse sur les apports du registre a été mené. Sur la question de ses liens avec les administrations sanitaires, les messages clés suivants ont été retenus. Une des finalités de REIN est de contribuer à mieux connaître la prise en charge des patients et de ses évolutions et ainsi être sollicité pour l'élaboration de stratégies sanitaires visant à améliorer la prévention et la prise en charge de l'insuffisance rénale chronique. En effet, la planification de l'offre et l'évaluation de la prise en charge sont des enjeux importants pour les décideurs en santé publique qui doivent disposer d'indicateurs et d'outils pertinents pour les aider dans leur décision avec leur suivi. REIN est clairement identifié comme source d'information par les partenaires institutionnels comme en témoignent les diverses sollicitations faites par les agences régionales de santé (ARS), la Haute Autorité de santé (HAS) ou la Direction générale de l'offre de soins (DGOS) mais également d'autres administrations sanitaires. Il permet d'estimer les besoins de la population dans le cadre des décrets nos 2002-1197 et 2002-1198 septembre 2002 relatifs au traitement de l'insuffisance rénale chronique par la pratique de l'épuration extrarénale. La récente possibilité d'appariement probabiliste des données de REIN aux données du Système national des données de santé (SNDS) pour un même individu pseudonymisé permet des études plus fines sur les différents parcours de soins, mais aussi d'évaluer l'impact des différentes actions ou expérimentations mises en place, avec l'aide des informations cliniques détaillées du REIN et, entre autres, les dépenses remboursées par l'Assurance maladie.

REIN: a tool at the service of vigilance and pharmaco-epidemiology / REIN : un outil au service de la vigilance et de la pharmaco-épidémiologie

On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue of its role in vigilance, the following key messages were retained. The vigilance system consists, among other things, of collecting information that is useful for the surveillance of health products that are drugs for pharmacovigilance, and medical devices for materiovigilance. This includes the reporting of adverse events by health professionals and manufacturers as well as the use of any information concerning the risk of adverse events. Vigilance enables improving and optimising product and patient safety by reducing the risks of adverse events and better understanding the risks and benefits. Using data from the REIN registry, cross-referenced with other external sources, it is possible to conduct post-marketing studies of these products. These studies generate hypotheses, are low-cost and are yet to be confirmed by randomised studies. Following the presentation of a study suggesting an unfavourable role of citrate dialysates on mortality, and thanks to the mobilisation of all the operators of the network, the REIN registry was able to conduct a study in a few months that made it possible to conclude that the use of citric acid in dialysates does not present a risk of excess mortality for the patients. With this example, the REIN registry has shown its adaptability and utility as a vigilance tool.

À l'occasion des 20 ans du REIN (Réseau Epidémiologie et Information en Néphrologie), un travail de synthèse sur les apports du registre a été mené. Sur la question de son rôle dans la vigilance, les messages clés suivants ont été retenus. Le système de vigilance consiste, entre autres, à recueillir des informations utiles à la surveillance des produits de santé que sont, pour la pharmacovigilance, les médicaments et, pour la matériovigilance, les dispositifs médicaux. Cela inclut le signalement d'évènements indésirables par les professionnels de santé et les industriels mais aussi l'exploitation de toute information concernant le risque d'évènements indésirables. La vigilance permet d'améliorer et d'optimiser la sécurité du patient et des produits en réduisant les risques d'évènements indésirables et de mieux appréhender les bénéfices-risques. À l'aide de données du registre REIN, croisées avec d'autres sources externes, il est possible de mener des études après la mise sur le marché de ces produits. Ces études génèrent des hypothèses, sont de faible coût et restent à confirmer par des études randomisées. Suite à la présentation d'une étude suggérant un rôle défavorable des dialysats au citrate sur la mortalité, et grâce à la mobilisation de tous les acteurs du réseau, le registre REIN a pu mener une étude en quelques mois qui a permis de conclure que l'utilisation de l'acide citrique dans les dialysats ne présente pas de risque de surmortalité pour les patients. Par cet exemple, le registre REIN a montré sa capacité d'adaptation et son utilité comme outil au service de la vigilance.

From transfer to transition: review and proposition of the SFNDT dialysis Commission / Du transfert à la transition : mise au point et proposition de la Commission de dialyse de la SFNDT

Over the course of their disease, patients with chronic kidney disease (CKD) will be treated by several kidney replacement therapy (KRT) modalities. The transitions between KRT modalities can be experienced as traumatic by patients, and are associated with an increased morbidity and mortality, notably when they are not anticipated. Planning these transition phases could reduce the psychological trauma induced by the transfer, as well as reduce the risk of morbidity and mortality. However, the lack of a clear definition of a transfer, and the lack of criteria enabling the identification of patients at risk of transfer, prevents the anticipation of these transition phases at high risk for patients. We here discuss the various possible causes and risk factors of transfer from peritoneal dialysis (PD) to hemodialysis as well as transfer from hemodialysis to PD. The dialysis Commission of the Société francophone de néphrologie, dialyse et transplantation (SFNDT) makes some proposals to improve transition phases, such as the identification of patients at risk, specific PD programs for unplanned PD start, transition unit and hybrid therapy.

Dans le parcours de soins du patient insuffisant rénal chronique, les différentes modalités de suppléance rénale vont se succéder dans le temps créant ainsi des phases de transition. Ces phases de transition peuvent être vécues comme traumatisantes par les patients, et sont associées à une augmentation de la morbi-mortalité, particulièrement lorsqu'elles ne sont pas suffisamment anticipées. La planification de ces phases de transition par l'équipe de dialyse devrait permettre de diminuer l'expérience du traumatisme psychologique induit par le changement et de réduire le risque de sur-morbi-mortalité. Cependant, l'absence de définition standardisée de la phase de transition entre modalités, le manque de critères et d'outils identifiant les patients à risque de transfert et l'absence d'infrastructures dédiées à ces patients transitionnels sont autant de facteurs limitant l'anticipation de ces phases de transition. Nous abordons ici les différentes causes et possibles facteurs de risque du transfert de la dialyse péritonéale (DP) vers l'hémodialyse ainsi que du transfert de l'hémodialyse vers la DP. Dans cette mise au point, la Commission de dialyse de la Société francophone de néphrologie, dialyse et transplantation (SFNDT) émet certaines propositions pour améliorer la définition et la prise en charge de ces phases de transition, et propose des outils d'identification des sujets « transitionnels ¼ ainsi que des exemples structurels de programmes soutenant la transition, tels que le démarrage en urgence de la DP, l'unité transitionnelle et la dialyse hybride.

A New Procedure for Guidewire Exchange of Tunneled Hemodialysis Catheters in Chronic Hemodialysis Patients: A Pilot Study.

INTRODUCTION: Different techniques of guidewire exchange of tunneled catheters for hemodialysis (HD) have been reported. This study was carried out to assess the feasibility of a new procedure in chronic HD patients who needed catheter exchange because of mechanical dysfunction. METHODS: The guidewire exchange method was based on the creation of a new exit site and a new subcutaneous tunnel while using the same venous insertion site. This was a retrospective study of exchanged tunneled catheters because of mechanical complications in patients on chronic HD between June 1, 2015, and December 31, 2019. The feasibility of the procedure was defined by successful exchange and catheter patency at 6 months. Catheter survival and immediate complications were reported. RESULTS: A total of 49 procedures were performed in 34 HD patients. There was no catheter insertion failure. At 6 months, 6 catheters have lost their patency because of a mechanical complication. Thus, the success rate of the procedure was 43/49 (87.8%). Catheter survival censored on death, transplantation, or vascular access creation was 97.8% at 90 days, 86.2% at 180 days, and 74.5% at 1 year. The median catheter survival was 10.2 months. Among the 49 procedures, there were 9 hematomas at the insertion site that did not require surgical intervention. Discussion/Conlusion: Our study shows that guidewire exchange of a tunneled HD catheter by creating a new exit site and a new subcutaneous tunnel by using the same venous access is a newer method in chronic HD patients. This procedure should not be used in patients with coagulation issues. Additional studies are needed to compare the different methods of HD catheter exchange.

Transitions between dialysis modalities.

Thanks to the progress of dialysis, survival of patients with end-stage renal disease is increasing. For those patients who cannot benefit from a kidney transplantation, several dialysis alternatives exist, but the transition between dialysis techniques may be difficult. Home dialysis offers many advantages but requires personal commitment from the patients and the caregivers. How can we ensure smooth transitioning to the best dialysis technique at the right time for the right person? One of the main caveats of peritoneal dialysis is its limited technique survival, however, it combines the advantages of preserving residual kidney function, avoiding the need for a vascular access, or preserving it, when present, while providing good cost-effectiveness. On the other hand, home hemodialysis has excellent long-term technique survival. The home integrated model of peritoneal dialysis followed by home hemodialysis has been described as the ideal pathway of care. Eventually, in-center hemodialysis can be provided according to several schedules to adapt to the needs of the patients. The issue of technique survival and the possible need to switch to another technique should be part of the initial discussion, when the patient needs to choose the first dialysis modality. Unplanned transfers are associated with poor outcomes and unwanted shifts to in-center hemodialysis. Therefore, transfers from home-based techniques should be anticipated as much as possible in order to establish a shared decision modality process and to choose the desired new modality. Dialysis units dedicated to "transition care" should answer the needs of patients and smooth the transition process between dialysis modalities.

Switch from Hemodialysis to Peritoneal Dialysis: Does the Time Spent on Hemodialysis Impact Outcomes in Peritoneal Dialysis?

INTRODUCTION: Switch from hemodialysis (HD) to peritoneal dialysis (PD) is unfrequent, but incentive strategies to perform PD can lead to an increase of these transitions. However, data on transitioning from HD to PD are scarce. We hypothesized that time spent on HD before transfer to PD would impact PD outcomes. METHODS: This registry-based, nationwide study analyzed patients transferred from HD to PD. Patients who began HD between January 2008 and December 2016 were included. Cox and Fine and Gray regression models were used to explore the relationship between time spent on HD before PD and outcomes in PD: PD cessation for death or retransfer to HD (composite endpoint); for death; and for retransfer to HD. RESULTS: Over the study period, 1,985 of the 77,587 HD starters (3%) were transferred to PD. The median time spent on HD before transfer to PD was 1.94 months (interquartile range [IQR] 1.02-4.01). The median survival time on PD after this transition was 20 months (IQR 18-21). Time spent on HD before PD was associated with increased risk of death or retransfer to HD (cause-specific hazard ratio [cs-HR] 1.01, 95% confidence interval [CI]: 1-1.02 for a 1-month increase) and death (cs-HR 1.02, 95% CI: 1.01-1.03) but not with retransfer to HD censored on death (cs-HR 1.00, 95% CI: 0.99-1.01). The results were similar when considering competing events. DISCUSSION/CONCLUSION: Switch from HD to PD is rare in France. Time spent on HD before transfer is associated with patient survival but not with retransfer to HD.

Dialysis-network variability in home dialysis use not explained by patient characteristics: a national registry-based cohort study in France.

BACKGROUND: Although associated with better quality of life and potential economic advantages, home dialysis use varies greatly internationally and appears to be underused in many countries. This study aimed to estimate the dialysis-network variability in home dialysis use and identify factors associated with (i) the uptake in home dialysis, (ii) the proportion of time spent on home dialysis and (iii) home dialysis survival (patient and technique). METHODS: All adults ≥18 years old who had dialysis treatment during 2017-2019 in mainland France were included. Mixed-effects regression models were built to explore factors including patient or residence characteristics and dialysis network associated with variation in home dialysis use. RESULTS: During 2017-2019, 7728/78 757 (9.8%) patients underwent dialysis at least once at home for a total of 120 594/1 508 000 (8%) months. The heterogeneity at the dialysis-network level and to a lesser extent the regional level regarding home dialysis uptake or total time spent was marginally explained by patient characteristics or residence and dialysis-network factors. Between-network heterogeneity was less for patient and technique survival. These results were similar when the analysis was restricted to home peritoneal dialysis or home hemodialysis. CONCLUSIONS: Variability between networks in the use of home dialysis was not fully explained by non-modifiable patient and residence characteristics. Our results suggest that to increase home dialysis use in France, one should focus on home dialysis uptake rather than survival. Financial incentives and a quality improvement programme should be implemented at the dialysis-network level to increase home dialysis use.

Impact of assistance on peritonitis due to breach in aseptic procedure in diabetic patients: A cohort study with the RDPLF data.

BACKGROUND: Diabetic patients often have physical impairment that could lead to manipulation errors in peritoneal dialysis (PD) and touch contamination. Nurse assistance in diabetic PD patients is known to help prevent peritonitis. We made the hypothesis that this lower risk of peritonitis was observed thanks to prevention of breach in aseptic procedure. We evaluated the impact of nurse-assisted PD on specific causes of peritonitis, especially on peritonitis due to a breach in aseptic procedure. METHODS: This was a retrospective observational study of the data from the French Language Peritoneal Dialysis Registry. All diabetic patients older than age 18 years starting PD in France between 1 January 2012 and 31 December 2015 were included in the study. The event of interest was the first peritonitis event due to a breach in aseptic procedure. Death, kidney transplantation and peritonitis due to another mechanism were considered as competing events. We examined the association of the covariates with all the possible outcomes using a subdistribution hazard model developed for survival analysis in the presence of competing risks. RESULTS: Four thousand one hundred one diabetic patients incident in PD were included in the study. At least one peritonitis event occurred in 1611 patients over the study period. A breach in aseptic procedure was reported in 441/1611 cases (27.3%): 209/575 (36.3%) in the self-care PD group, 56/217 (25.8%) in the family-assisted PD group and 176/819 (21.5%) in the nurse-assisted PD group. Both nurse and family assistance were associated with a lower risk of peritonitis due to breach in aseptic procedure in bivariate analysis. After adjustment on age, modified Charlson index, sex and diabetic nephropathy, patients treated by nurse-assisted PD (subdistribution hazard ratio (sd-HR) 0.52, 95% confidence interval (CI) 0.40-0.67) and those treated by family-assisted PD (sd-HR 0.70, 95% CI 0.51-0.95) had a lower likelihood of peritonitis due to a connection error compared to self-care PD in multivariate analysis. The modality of assistance was not associated with other causes of peritonitis in the multivariate analysis. CONCLUSION: While both nurse-assisted PD and family-assisted PD were associated with lower risk of peritonitis due to a breach in aseptic procedure compared to self-care PD in our study, the protective effect was greater with nurse assistance.